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KMID : 0371319970520040606
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Journal of the Korean Surgical Society
1997 Volume.52 No. 4 p.606 ~ p.614
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Perioperative Studies of focal & Type Nesidioblastosis in Adult -2 cases report)
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Abstract
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Nesidioblastosis is a term that describes the prolonged differentiation of the Langerhan's islet cells from the epithelium of the pancreatic duct. 80% of Islet cell lesions accompanied with benign islet cell tumors. The additional 10% are
malignant
and
the remaining are nesidioblastosis. Children are susceptible and can develop hyperinsulinemic hypoglycemia, but it is rare in adults. Only 20 cases have been reported worldwide. 6 of them in Korea. A 41-year old man & 42-year old woman were
admitted due
to intermittent hypoglycemic symptoms, that had been relieved by carbohydrate ingestion. Hyperinsulinemic hypoglycemia was documented during prolonged fasting. Under the presumptive diagnosis of insulinoma, Abdominal CT, Celiac angiogram and
percutaneous transhepatic portal venous sampling were done, but we could not find any definitive mass. 85% of the pancreas & 88%of the pancreas was removed respectively. Pathologic examination of the resected pancreas revealed irregularly sized
islets
and scattering of small endocrine cell clusters throughout the acinar tissue and ductuloinsular complex.
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KEYWORD
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